首发未用药抑郁症患者大五人格特征对照研究

目的探讨首发未服药抑郁症患者的大五人格特征。方法采用大五人格量表简化版(neuroticism extraversion openness five-factor inventory,NEO-FFI),对112例首发未服药抑郁症患者及99名性别、年龄、文化背景相匹配的正常对照进行大五人格特征评估,汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评定患者的抑郁症状。结果患者组神经质维度得分高于对照组,而外向性、开放性、宜人性及责任感维度得分均低于对照组(P0.05)。Logistic回归分析示,抑郁症与高水平神经质(OR=1.106,95%CI:1.029~1.189)、低水平外向性(OR=0.809,95%CI:0.733~0.893)和宜人性(OR=0.870,95%CI:0.794~0.953)相关联(均P0.01)。线性回归分析示,HAMD评分仅与高水平神经质相关(B=0.121,P=0.003),发病年龄则与责任感维度得分相关(B=0.015,P=0.001)。结论本研究确认了抑郁症患者人格维度与正常对照有差异,高水平神经质维度是首发抑郁症患者的重要人格因素特征,低水平责任感则可能与抑郁症发病年龄早有关。

A comparison study of the big five personality characteristics in patients with first-episode,treatment-naive major depressive disorder

Objective To explore the big five personality characteristics of the first-episode, treatment-naive major depressive disorder. Method Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI) was used to assess the personality. A comparison was conducted between 112 first-episode, treatment-naive major depressive disorder (MDD) patients and 99 sex-, age- and education level-matched healthy controls (HC). The Hamilton depression scale (HAMD) was used to evaluate patients’symptom. Result Compared with HC, the neuroticism score in MDD group was significantly higher, while the extraversion, openness, agreeableness and conscientiousness were significantly lower. Lo?gistic regression analysis showed that MDD was significantly associated with higher neuroticism (OR=1.106, 95%CI:1.029~1.189, P=0.006) and lower extraversion (OR=0.809, 95%CI: 0.733~0.893, P<0.001) and agreeableness (OR=0.870, 95%CI:0.794~0.953, P=0.003). Linear regression showed that the HAMD score was significantly associated with higher neuroticism (B=0.121, P=0.003). The onset age of MDD was significantly associated with conscientiousness (B=0.015, P=0.001). Conclusion This study confirms that the personality of MDD is different from HC. Higher neuroticism is an important personality facets in treatment-naive patients with first-episode MDD. The low conscientiousness might associate with early age of depression onset.