Node-by-node correlation between MR and PET/CT in patients with uterine cervical cancer: diffusion-weighted imaging versus size-based criteria on T2WI |
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Authors: | Eugene K Choi Jeong Kon Kim Hyuck Jae Choi Seong Ho Park Bum-Woo Park Namkug Kim Jae Seung Kim Ki Chun Im Gyunggoo Cho Kyoung-Sik Cho |
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Institution: | 1. Department of Radiology, Asan Medical Center, University of Ulsan, 388-1 Poongnap dong, Songpa-gu, Seoul, 138-736, Korea 2. Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA, 90095-1721, USA 3. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan, 388-1 Poongnap dong, Songpa-gu, Seoul, 138-736, Korea 4. Bio-MR center, Korea Basic Science Institute, 804-1 Yangcheong-ri, Ochang-eup, Cheongwon-gun, Chungcheongbuk-do, 363-883, Korea
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Abstract: | The purpose of the study was to perform a node-by-node comparison of an ADC-based diagnosis and various size-based criteria
on T2-weighted imaging (T2WI) with regard to their correlation with PET/CT findings in patients with uterine cervical cancer.
In 163 patients with 339 pelvic lymph nodes (LNs) with short-axis diameter >5 mm, the minimum apparent diffusion coefficient
(ADC), mean ADC, short- and long-axis diameters, and ratio of long- to short-axis diameters (L/S ratio) were compared in PET/CT-positive
and -negative LNs. On PET/CT, 118 (35%) LNs in 58 patients were positive. The mean value of minimum and mean ADCs, short-
and long-axis diameters, and L/S ratio were different in PET/CT-positive (0.6436 × 10−3 mm2/s, 0.756 × 10−3 mm2/s, 10.3 mm, 13.2 mm, 1.32, respectively) and PET/CT-negative LNs (0.8893 × 10−3 mm2/s, 1.019 × 10−3 mm2/s, 7.4 mm, 11.0 mm, 1.49, respectively) (P < 0.05). The Az value of the minimum ADC (0.864) was greater than those of mean ADC (0.836), short-axis diameter (0.764), long-axis diameter
(0.640) and L/S ratio (0.652) (P < 0.05). The sensitivity and accuracy of the minimum ADC (86%, 82%) were greater than those of the short-axis diameter (55%,
74%), long-axis diameter (73%, 58%) and L/S ratio (52%, 66%) (P < 0.05). ADC showed superior correlation with PET/CT compared with conventional size-based criteria on T2WI. |
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Keywords: | Diffusion magnetic resonance imaging Lymphatic metastasis Lymph nodes Uterine cervical neoplasms Comparative study |
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