虎杖化学成分及药理活性研究进展

虎杖Polygoni Cuspidati Rhizomaet Radix在中国已有数千年治疗和预防疾病的历史,可用于改善腹泻、咳嗽、黄疸、炎症、闭经、烧伤和高脂血等症状.虎杖化学成分包括醌类、二苯乙烯类、黄酮类、苯丙素类等化合物.现代药理学和临床研究表明,虎杖可用于治疗炎症、糖尿病、痛风、癌症、病毒性疾病、细菌感染性疾...

Research development on chemical composition and pharmacology of Polygoni Cuspidati Rhizoma et Radix

Huzhang (Polygoni Cuspidati Rhizoma et Radix) has been widely used to treat and prevent diseases in China for thousands of years. The therapeutic application of Polygoni Cuspidati Rhizoma et Radix is used for ameliorating diarrhea, cough, jaundice, inflammation, amenorrhea, burn and hyperlipemia, etc. Chemical compounds isolated and identified from this plant included quinones, stilbenes, flavonoids, and phenylpropanoids, etc. Recent pharmacological and clinical research experiments showed that Polygoni Cuspidati Rhizoma et Radix could be used for the treatment of diseases such as inflammation, diabetes, gout, cancer, viral diseases, bacterial infectious diseases, neurodegenerative diseases and other diseases. In particular, it has a good inhibitory effect on respiratory diseases caused by coronavirus. This article systematically summarizes the domestic and foreign research literatures of Polygoni Cuspidati Rhizoma et Radix in recent years, and reviews from the perspective of chemical components corresponding to the pharmacological effects, provides a basis for the further development and application of Polygoni Cuspidati Rhizoma et Radix medicinal resources, and also provides a scientific basis for the application of Polygoni Cuspidati Rhizoma et Radix in combating the new coronavirus pneumonia.