青黛治疗溃疡性结肠炎的机制研究进展

溃疡性结肠炎(ulcerative colitis,UC)是一种与自身免疫相关的慢性非特异性肠道炎症性疾病,中医认为UC的病理性质为本虚标实,病理因素主要包括湿、热、瘀、毒等,青黛有清热解毒、凉血消斑之效,作为复方制剂的重要成分之一,被长期用于UC的口服或局部治疗中。近年来研究者采用青黛单药及其主要成分口服或纳肛治疗UC亦取得良好效果,并针对其作用机制开展了大量研究。本文主要归纳总结了近年来青黛及其有效成分提取物(靛玉红、靛蓝、色胺酮)等治疗UC的机制研究。

ResearchProgress on the Mechanism of Indirubin Naturalis in the Treatment of Ulcerative Colitis

Ulcerative colitis (UC) is a chronic intestinal inflammatory disease associated with autoimmunity. The traditional treatment of UC mainly includes 5-aminosalicylic acid (5-ASA), corticosteroids, and immunosuppressant. The pathogenesis of UC in traditional Chinese medicine is characterized by deficiency in origin and excess in superficiality. Etiological factors mainly include dampness, heat, blood stasis and toxin. Indigo naturalis, which can clear away heat and toxic material, cool blood and eliminate spots, has been widely used in the treatment of UC for a long time. In recent years, researchers have also achieved good results in the treatment of UC with taking Indigo naturalis alone and its main effective components orally or anus, and a large number of studies have been carried out on its mechanism. This review focuses on the researches on the mechanism of indirubin naturalis and its effective components (indirubin, indigo and tryptanthrin) in the treatment of UC in recent years.