| CYP3A5和MDR1基因型对尿毒症患者肾移植术后早期他克莫司血药浓度和肌酐水平的影响 |
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| 引用本文： | 温燕,朱德康,傅尚希,邓易,张凤,陈万生.CYP3A5和MDR1基因型对尿毒症患者肾移植术后早期他克莫司血药浓度和肌酐水平的影响[J].药学实践杂志,2022,40(2):165-170. |
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| 作者姓名： | 温燕 朱德康 傅尚希 邓易 张凤 陈万生 |
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| 作者单位： | 海军军医大学第二附属医院药剂科, 上海 200003;海军军医大学第二附属医院教务处, 上海 200433;海军军医大学第二附属医院第二附属医院器官移植科, 上海 200003 |
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| 基金项目： | 院创新型临床研究资助（2020YLCYJ-Y25）；上海市临床药学重点专科建设项目（2016-40044-002）；上海市卫生计生系统重要薄弱学科建设项目（2016ZB0303）；上海市“医苑新星”青年医学人才资助（2020临床药师项目）；国家自然科学基金（81573793） |
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| 摘 要： | 目的 评价真实临床实践中CYP3A5(CYP3A5*3,6986A>G)及MDR1(C3435>T,G2677>T/A,C1236>T)基因多态性对尿毒症患者接受肾移植术后早期他克莫司血药浓度的影响及其最佳治疗浓度.方法 以入选2013～2017年单中心的131例首次肾移植术且术后以他克莫司为基础进行三联免疫治疗的患者...
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| 关 键 词： | 肾移植 他克莫司 肌酐 CYP3A5 MDR1 |
| 收稿时间： | 2020/9/26 0:00:00 |
| 修稿时间： | 2022/1/4 0:00:00 |
Effect of CYP3A5 and MDR1 gene polymorphism on blood concentration of tacrolimus and creatinine level in uremic patients during the early phase of kidney transplantation |
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| WEN Yan,ZHU Dekang,FU Shangxi,DENGYi,ZHANG Feng,CHEN Wansheng.Effect of CYP3A5 and MDR1 gene polymorphism on blood concentration of tacrolimus and creatinine level in uremic patients during the early phase of kidney transplantation[J].The Journal of Pharmaceutical Practice,2022,40(2):165-170. |
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| Authors: | WEN Yan ZHU Dekang FU Shangxi DENGYi ZHANG Feng CHEN Wansheng |
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| Institution: | Naval Medical University of the PLA, Department of Pharmacy, Second affiliated Hospital, Shanghai 200003;Naval Medical University of the PLA, Department of Academic Administrative Affairs, Shanghai 200433, China;Naval Medical University of the PLA, Department of Organ Transplantation, Shanghai 200003, China |
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| Abstract: | Objective To investigate the effect of CYP3A5 and MDR1 gene polymorphisms on blood concentration of tacrolimus and creatinine level in uremic patients during the early phase after kidney transplantation in real clinical practice. Methods 131 patients who underwent kidney transplantation for the first time with triple immunotherapy based on tacrolimus in single-center from 2013 to 2017 were enrolled for retrospective study. Tacrolimus daily dose, blood concentration, blood concentration-to-dose ratio, and serum level were compared according to the various genotypes of CYP3A5 and MDR1 polymorphisms in renal transplantation recipients, respectively. Results The dosage of tacrolimus in CYP3A5*3/*3 (GG) kidney transplantation recipients within 4 weeks after kidney transplantation was lower than those of CYP3A5*1/*1 (AA) and CYP3A5*1/*3 (AG). The serum creatinine levels of patients whose tacrolimus concentration in the range of 10-13 ng/ml were close to the normal value. Conclusion CYP3A5 gene polymorphism affects the blood concentrations of tacrolimus in renal transplant recipients. No association has been found between the blood concentrations of tacrolimus and MDR1 gene polymorphism. Tacrolimus concentration in the range of 10-13 ng/ml might contribute to restore the early kidney graft function. |
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| Keywords: | tacrolimus kidney transplantation creatinine CYP3A5 MDR1 |
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