中性粒细胞胞外诱捕网与胰腺疾病的研究进展

中性粒细胞胞外诱捕网(NETs)是近年来研究的热点,是中性粒细胞杀灭病原体的一种新的免疫机制.越来越多的研究表明,NETs参与了心血管疾病、胆结石的形成、炎症、肿瘤等疾病的病理生理过程.研究显示,NETs是急性胆源性胰腺炎(ABP)的发病机制之一、是急性胰腺炎(AP)病情进展的重要因素,也是促进胰腺癌细胞的增殖、转移、...

Research progress of the role of neutrophil extracellular traps in pancreatic diseases

A novel immune mechanism for neutrophil killing of pathogens, termed neutrophil extracellular traps (NETs), has become a hot topic of research in recent years. An increasing number of studies have shown that formation of NETs is involved in the pathophysiological processes of cardiovascular diseases, gallstone formation, inflammation, tumors and other diseases. Studies demonstrated that the presence of NETs is one of the pathogenesis of acute biliary pancreatitis (ABP) and an important factor in the progression of acute pancreatitis (AP), and furthermore, it is also a key factor in promoting the proliferation and metastasis of pancreatic cancer cells, as well as participating in the venous thrombus formation of pancreatic cancer patients. Here, the authors address the related topics.