慢性阻塞性肺疾病急性期血清白细胞介素-6、白细胞介素-13和白细胞介素-17A水平与GOLD分级的关系

目的 通过检测慢性阻塞性肺疾病(COPD)急性加重期和稳定期前后血清白细胞介素6(IL-6)、白细胞介素13(IL-13)和白细胞介素17A(IL-17A)的水平变化,探讨IL-6、IL-13和IL-17A在COPD急性加重期中的作用.方法 选取2017年1月至2018年6月上海市静安区市北医院呼吸内科收治的COPD急...

Relationship between serum IL-6, IL-13 and IL-17a levels with GOLD grade in acute stage of chronic obstructive pulmonary disease

Objective To discuss the role of serum IL-6, IL-13, and IL-17a levels in acute exacerbation of COPD by measuring the levels of serum IL-6, IL-13 and IL-17a during acute exacerbation and stabilization state.Methods Forty-two patients who were admit ted to the respiratory department of Shibei Hospital from January 2017 to June 2018 were selected as the AECOPD group. After anti-infection and symptomatic treatment, 42 patients were assigned to the stable COPD group. The serum of each group was collected todetect IL-6, IL-13, and IL-17a by double antibody cardioversion (ELISA), and the blood c-reactive protein (CRP), calcitonin (PCT),sedimentation, white blood cells, neutrophil and eosinophil Numbers were also collected and detected. Lung function was used to eval uate the GOLD classification of COPD in stable state.Results C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), PCT, white blood cell count (WBC), neutrophil count (Neu), IL-6, IL-13 and IL-17a were significantly different between stable COPD and acute COPD (P < 0.01). CRP, ESR, PCT, white blood cell count, neutrophil count, IL-6, IL-13 and IL-17a in acute phase of COPD were significantly higher than those in stable phase(P<0.05). The serum levels of IL-6, IL-13 and IL-17a in patients with COPD before and after treatment were significantly different (P < 0.01). The levels of serum IL-13 and IL-17a increased with the GOLD grading. Gold grade was positively correlated with serum IL-13 ( r = 0.58, P < 0.01) and IL-17a (r = 0.53, P < 0.01), but not with IL-6(r = 0.25, P = 0.114). The serum IL-17a level of patients in stable phase was significantly different from that of gold classification (P < 0.01), and was positively correlated with gold classification (r = 0. 566, P < 0.01).Conclusion IL-6, CRP, PCT, erythrocyte sedimen tation rate, white blood cell count, neutrophil count and so on are all increased in acute exacerbation of COPD but lack of specificityand correlation. The level of IL-13 is positively correlated with GOLD grade, while the level of IL-17a is correlated with airway inflam mation and remodeling in COPD. Combined detection of IL-6, IL-13 and IL-17a related cytokines can better guide the management and treatment of patients with COPD.