中药熏蒸与湿敷治疗面部皮炎短期临床疗效对比

目的:对比皮肤康洗液熏蒸与湿敷两种方法短程治疗面部皮炎的临床疗效。方法:将63例面部皮炎患者随机分为两组。治疗组予皮肤康洗液熏蒸,对照组予皮肤康洗液湿敷,均1次/d,连续治疗3 d。两组均同时口服咪唑斯汀片和外用透明质酸修护生物膜。观察治疗前后两组临床症状和体征积分、皮肤检测仪(VISIA)检测的红色区绝对分值、皮肤生理测试仪测量的红斑指数(erythema index,EX)和经皮水丢失(transepidermal water loss,TEWL)变化,评估临床疗效,并记录不良反应。结果:治疗3 d后,61例患者完成随访,其中治疗组31例,有效率70.97%(22/31),对照组30例,有效率46.67%(14/30),差异无统计学意义(χ²=3.72,P>0.05)。治疗后两组患者的瘙痒、灼热、干燥/紧绷、刺痛、红斑、丘疹、水肿、脱屑和皮损面积积分、VISIA红色区绝对分值、EX和TEWL均较本组治疗前明显下降,差异均有统计学意义(P<0.05)。治疗后瘙痒、刺痛、皮损面积积分以及VISIA红色区绝对分值和EX治疗组明显低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:皮肤康洗液2种治疗方法短期内均可以安全有效治疗面部皮炎,熏蒸法在改善瘙痒、刺痛、红色区绝对分值和EX方面优于湿敷法。

Comparison of Short-term Clinical Efficacy of the Treatment of the Facial Dermatitis with the Fumigation and Wet Application of the Traditional Chinese Medicine

Objective:To compare the short-term clinical efficacy of facial dermatitis treated with fumigation and wet application of Pifukang Lotion.Methods:63 patients with facial dermatitis were randomly divided into two groups.The treatment group was treated with local fumigation of Pifukang Lotion and the control group was treated with wet application of Pifukang Lotion,once a day for 3 days.Both groups were given Mizolastine Tablet and hyaluronic acid repairing biofilm together.The changes of clinical symptoms and signs,and the absolute score of the red area were detected by VISIA;the erythema index(EX)and the transdermal water loss(TEWL)were measured by skin physiological tester.After the treatment,the clinical efficacy was evaluated,and side effects were recorded.Results:61 cases completed 3 days of the treatment,including 31 cases in the treatment group,with an effective rate of 70.97%;30 cases in the control group,with an effective rate of 46.67%;the difference was not statistically significant(χ²=3.72,P>0.05).The scores of pruritus,burning sensation,dryness and tingling,erythema,papule,swelling,desquamation and lesion area,the absolute score of VISIA red area,EX and TEWL were significantly lower after the treatment than those before the treatment in the two groups(P<0.05).The scores of pruritus,tingling and lesion area,the absolute score of VISIA red area and EX were significantly lower in the treatment group than those in the control group after the treatment(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Both methods of Pifukang Lotion are safe and effective in the treatment of facial dermatitis,but fumigation therapy is better than the wet application method in the improvement of pruritus,tingling,absolute score of red area and EX.