In vitro analyses of ethanol activity against Candida albicans biofilms |
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| Authors: | Rane Hallie S Bernardo Stella M Walraven Carla J Lee Samuel A |
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| Affiliation: | Section of Infectious Diseases, New Mexico Veterans Healthcare System, Albuquerque, New Mexico, USA. |
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| Abstract: | Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI). Ethanol (EtOH) lock therapy has been attempted despite limited data on optimal dose and duration. Concentrations of 35% EtOH or higher for a minimum of 4 h demonstrated a >99% reduction in mature C. albicans biofilm metabolic activity and prevented regrowth. Concentrations of 10% EtOH or higher reduced C. albicans biofilm formation by >99%. Further investigation of EtOH lock therapy for treatment and prevention of C. albicans CR-BSI is warranted. |
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