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| 七叶皂苷钠对肺部急性炎性渗出的影响 | |
| 引用本文： | 潘丽丽,牛建昭,王振华,张雷明,傅风华. 七叶皂苷钠对肺部急性炎性渗出的影响[J]. 中国药师, 2010, 13(3): 321-323 |
| 作者姓名： | 潘丽丽 牛建昭 王振华 张雷明 傅风华 |
| 作者单位： | 1. 烟台大学药学院,山东,烟台,264005;山东绿叶制药有限公司 2. 北京中医药大学 3. 烟台大学药学院,山东,烟台,264005 |
| 基金项目： | 国家自然科学基金资助项目，"重大新药创制"科技重大专项"十一五"计划资助项目 |
| 摘 要： | 目的：研究七叶皂苷钠对肺部急性炎性渗出的作用。方法：以乙酸所致的腹腔毛细血管通透性增高模型小鼠观察七叶皂苷钠对急性渗出作用的时效关系；以肾上腺素致大鼠急性肺水肿和内毒素致小鼠急性肺损伤模型，观察七叶皂苷钠对急性肺部炎症渗出的影响。结果：七叶皂苷钠抑制急性炎症渗出作用的起效较慢，给药5h后作用开始较为明显，作用可持续24h；预防给药，可明显降低急性肺水肿大鼠的死亡率；对肾上腺素及内毒素所致肺部炎症也有明显抑制作用。结论：七叶皂苷钠可用于急性肺炎中肺部急性炎症渗出的防治。 |
| 关 键 词： | 七叶皂苷钠 肺炎 肺水肿 |
Effects of Escin on Acute Inflammation of Lung |
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| Pan Lili,Niu Jianzhao,Wang Zhenhua,Zhang Leiming,Fu Fenghua. Effects of Escin on Acute Inflammation of Lung[J]. China Pharmacist, 2010, 13(3): 321-323 | |
| Authors: | Pan Lili Niu Jianzhao Wang Zhenhua Zhang Leiming Fu Fenghua |
| Affiliation: | 1. School of Pharmacy, Yantai University, Shandong Yantai 264005, China; 2. Shandong Luye Pharmaceutical Limited; 3. Beijing University of Chinese Medicine) |
| Abstract: | Objective： To investigate the effects of escin （ sodium aeseinate） on acute infla ruination of lung. Method： The timeeffects of esein on inhibiting the capillary permeability in mice was made firstly and the protective effects of escin on the acute pulmonary edema induced by epinephrine in rats or the pneumonia induced by lipopolysaecharide （LPS） in mice were observed. Result： Five hours after administration esein showed a inhibition of the permeability of capillary vessel in mice and could maintain for 24 h. Both the mortality of rat with pulmonary edema and the weight of lungs in mice with acute pneumonia were decreased significantly after administration of esein. Conclusion： Escin is a useful drug for both preventing and treating of acute inflammation of lung. |
| Keywords: | Esein Pneumonia Pulmonary edema |
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