A quality-adjusted survival analysis (Q-TWiST) of rituximab plus CVP vs CVP alone in first-line treatment of advanced follicular non-Hodgkin's lymphoma |
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Authors: | R Marcus R Aultman and F Jost |
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Institution: | 1Department of Haematology, Kings College Hospital, London, UK;2F. Hoffmann-La Roche Ltd, Basel, Switzerland |
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Abstract: | Background: To evaluate the impact of treatment on health states that affect patients'' quality of life in advanced follicular lymphoma.Methods: A quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TwiST) analysis was performed on data from a phase III clinical trial (Marcus et al, 2008).Results: Cyclophosphamide, vincristine, and prednisone plus rituximab (R-CVP)-treated patients gained a mean of 15.17 months in TWiST, 8.33 months in Q-TwiST, and 11.30 months less in disease relapse, without increase in toxicity compared with cyclophosphamide, vincristine, and prednisone (CVP)-treated patients.Conclusion Rituximab plus CVP-treated patients reached a significant and clinically meaningful improvement within 12 months in quality-adjusted survival compared with CVP. |
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Keywords: | follicular lymphoma cyclophosphamide vincristine and prednisone rituximab quality-adjusted survival health-related quality of life quality-adjusted time without disease symptoms or toxicities of treatment |
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