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Age of onset in familial breast cancer as background data for medical surveillance |
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| Authors: | A Brandt J Lorenzo Bermejo J Sundquist K Hemminki |
| Affiliation: | 1Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), 69120 Heidelberg, Germany;2Institute of Medical Biometry and Informatics, University Hospital Heidelberg, 69120 Heidelberg, Germany;3Center for Primary Care Research, Lund University, 205 02 Malmö, Sweden;4Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California 5411, USA |
| Abstract: | Background:Familial breast cancers are known to be of early onset. This article provides differences in the age of onset of breast cancer and death by breast cancer between women with and without a family history.Methods:The Swedish Family-Cancer Database was used to estimate the cumulative risk of breast cancer and death by breast cancer according to family history with a stratified Cox model. Family history was defined separately for affected mother or sister considering their diagnostic ages.Results:The age to reach the same cumulative incidence as women without family history decreased with decreasing diagnostic age of the affected relative. Women with a maternal history reached the risk of women lacking a family history at the age of 50 years between 12.3 (mother affected <40 years) and 3.3 years (mother affected >82 years) earlier. The trend for breast cancer mortality was essentially similar.Conclusions:Women with mother or sister affected by breast cancer are diagnosed and die at earlier ages than do women without family history. The differences depend on the diagnostic age of the affected relative. The present data may provide a rationale to derive recommendations for the starting age of screening in women with affected family members. |
| Keywords: | breast cancer familial breast cancer age of onset screening recommendations cumulative risk |