White matter microstructure in patients with obsessive-compulsive disorder |
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Authors: | Bora Emre Harrison Ben J Fornito Alex Cocchi Luca Pujol Jesus Fontenelle Leonardo F Velakoulis Dennis Pantelis Christos Yücel Murat |
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Institution: | Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia. emrebora@hotmail.com |
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Abstract: | BackgroundPrevious diffusion tensor imaging (DTI) studies in patients with obsessive–compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination.MethodsIn this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls.ResultsWe found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity.LimitationsThe cross-sectional design was the main limitation.ConclusionOur findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD. |
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