| 新型口服链阳性菌素——XRP2868 |
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| 引用本文： | 顾觉奋,周娴. 新型口服链阳性菌素——XRP2868[J]. 抗感染药学, 2008, 5(1): 1-5 |
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| 作者姓名： | 顾觉奋 周娴 |
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| 作者单位： | 中国药科大学生命科学与技术学院,江苏,南京,210009 |
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| 摘 要： | XRP2868，一种新型口服链阳性菌素，通过研究其药物动力学和药效学，并与其他抗生素进行对比，发现具有较广的抗菌谱，可用于耐药的革兰阳性球菌，具有较大的临床研究前景。笔者就其化学结构、组成、药代动力学和药效学、抗菌活性、作用机制及耐药机制作简要概述。
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| 关 键 词： | XRP2868 口服链阳性菌素 药物动力学 药效学 耐药机制 |
| 文章编号： | 1672-7878(2008)01-0001-05 |
| 修稿时间： | 2007-09-20 |
New-type Oral Streptogramin XRP 2868 |
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| GU Jue-fen,ZHOU Xian. New-type Oral Streptogramin XRP 2868[J]. Anti-infection Pharmacy, 2008, 5(1): 1-5 |
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| Authors: | GU Jue-fen ZHOU Xian |
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| Affiliation: | (Institute of Life Science and Technology, China Pharmaceutical Univercity, Nanjing 210009, China) |
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| Abstract: | XRP 2868,a novel oral streptogramin,compared to the other antibiotics,has a wide antibacterial spectrum,including gram-positive cocci,fastidious gram-negative rods involved in respiratory tract infection,and anaerobes,which are potential for the further clinical research.The structures of the components of XRP 2868,pharma- cokinetics and pharmacodynamics,bioactivities,action mechanism and resistance mechanism were overviewed,briefly. |
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| Keywords: | XRP2868 oral streptogramin pharmacokinetics pharmacodynamics resistance mechanism |
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