房间隔缺损患者介入封堵前后心肌酶谱变化的意义探讨

目的 观察经皮介入封堵治疗房间隔缺损(ASD)前后心肌酶谱的变化,探讨其影响因素及其对患者预后的影响.方法 检测ASD患者介入手术治疗前后肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、血清肌钙蛋白(cTnI)、乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)和α-羟丁酸脱氢酶(α-HBD)水平,对治疗前后资料进行对比分析.结果 ASD患者介入封堵术治疗后AST和cTnI水平较治疗前明显升高,差异均有统计学意义(P<0. 05);血清LDH、CK-MB、CK和α-HBD水平治疗前后差异无统计学意义(P>0. 05).结论 经导管介入ASD封堵术治疗对患者心肌酶有一定影响,尤其是对AST和cTnI的影响明显.该影响可用适当药物干预,但其对患者的预后影响不明显.

Changes of Myocardial Enzymes in Patients with Atrial Septal Defect Before and After Transcatheter Closure and the Significance

Objective To observe the changes of myocardial enzymes in patients with atrial septal defect (ASD) before and after transcatheter closure and to discuss the influencing factors and the impact on prognosis. Methods The levels of CK, CK-MB, cTnI, LDH, AST andα-HBD in patients with ASD before and after transcatheter closure were detected and a comparative study was made. Re-sults The levels of AST and cTnI after transcatheter closure were much higher than those before transcatheter closure with a statistical difference (P<0.05);there existed no statistical difference between the levels of serum LDH, CK-MB, CK andα-HBD before transcath-eter closure and those after transcatheter closure (P<0.05). Conclusions Transcatheter closure is of certain impact on the myocardial en-zymes of the patients with ASD, especially on the levels of AST and cTnI, which may be intervened by proper drugs, and it will produce no obvious impact on the prognosis of the patients.