The impact of oral disease and nonsurgical treatment on bacteremia in children |
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Authors: | Brennan Michael T Kent M Louise Fox Philip C Norton H James Lockhart Peter B |
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Affiliation: | Department of Oral Medicine, Carolinas Medical Center, P.O. Box 32861, Charlotte, NC 28232, USA. mike.brennan@carolinas.org |
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Abstract: | BACKGROUND: The authors examine the role of dental disease and nonsurgical dental procedures in the incidence and duration of bacteremia in children. METHODS: The authors randomized a group of children to receive amoxicillin or a placebo before dental rehabilitation in an operating room setting. They collected eight blood draws at the following times: two minutes after intubation (draw 1); after dental restorations, pulp therapy and cleaning (draw 2); 10 minutes later (draw 3); and five draws during and after dental extractions (draws 4-8). The authors compared dental disease parameters and the type of dental procedures performed with the incidence and duration of bacteremia. RESULTS: The authors enrolled 100 children (aged 1-8 years) in the study. The incidence of bacteremia from draw 2 was 20 percent in the placebo group and 6 percent in the amoxicillin group (P = .07), and the incidence from draw 3 was 16 percent in the placebo group and zero percent in the amoxicillin group (P = .03). Subjects with higher gingival scores were more likely to have a bacteremia for draw 2 (P = .01). The authors found that subjects in the group with bacteremia for draw 3 had undergone more pulpotomies than did subjects in the group without bacteremia for draw 3 (3 +/- 2.5 standard deviation [SD] versus 1.5 +/- 1.6 SD, P = .04), while they found almost no differences for draw 2. CONCLUSIONS: This study suggests that gingival disease has an impact on bacteremia after dental restorations and prophylaxis. Although antibiotics have an impact, they do not eliminate bacteremia altogether. |
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Keywords: | Bacteremia infective endocarditis pediatric dental care gingival diseases AHA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw60" }," $$" :[{" #name" :" text" ," _" :" American Hospital Association IE" },{" #name" :" keyword" ," $" :{" id" :" cekeyw80" }," $$" :[{" #name" :" text" ," _" :" Infective endocarditis IND" },{" #name" :" keyword" ," $" :{" id" :" cekeyw100" }," $$" :[{" #name" :" text" ," _" :" Incidence, nature (species of bacteria) and duration OR" },{" #name" :" keyword" ," $" :{" id" :" cekeyw120" }," $$" :[{" #name" :" text" ," _" :" Operating room |
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