乌鸡白凤丸与阿立哌唑治疗利培酮所致女性精神分裂症患者 高催乳素血症的对照研究

目的 探讨乌鸡白凤丸与阿立哌唑对女性精神分裂症患者服用利培酮所致高催乳素血症的影响及其安全性。方法 将 应用利培酮治疗导致高催乳素血症的 67 例女性精神分裂症患者随机分为乌鸡白凤丸组和阿立哌唑组，疗程 4 周。结果 乌鸡白凤丸组完成 28 例，阿立哌唑组完成 30 例，乌鸡白凤丸组血清催乳素明显低于入组前（t=7.624，P=0.000），阿立 哌唑组血清催乳素明显低于入组前（t=8.278，P=0.000），两组血清催乳素水平无明显差异（t=1.965，P=0.054）。结论 乌 鸡白凤丸与阿立哌唑均能降低利培酮所致高催乳素水平，安全性好。

Control study of Wujibaifeng pills and aripiprazole in the treatment of female schizophrenia patients with hyperprolactinemia split caused by risperidone

Objective To explore the efficacy and safety of Wujibaifeng pills and aripiprazole in the treatment of female hyperprolactinemia caused by risperidone. Methods 67 female schizophrenia patients with hyperprolactinemia caused by risperidone and aripiprazole were randomly assigned into Wujibaifeng pills group and aripiprazole group treated for 4 weeks. Results In Wujibaifeng pills group 28 cases were completed the treatment, in aripiprazole group 30 cases completed. In Wujibaifeng pills group, the serum prolactin was significantly lower than before treatment (t=7.624, P=0.000), serum prolactin in aripiprazole group was significantly lower than that before treatment (t=8.278, P=0.000). The serum prolactin levels in the two groups had no significant difference (t=1.965, P=0.054) .Conclusion Wujibaifeng pills and aripiprazole can reduce risperidone induced hyperprolactinemia level with good safety.