| 诺氟沙星(Norfloxacin)合成工艺的改进 |
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| 引用本文： | 纪耿豪. 诺氟沙星(Norfloxacin)合成工艺的改进[J]. 中国现代应用药学, 1991, (4): 14-15. |
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| 作者姓名： | 纪耿豪 |
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| 作者单位： | 深圳仙诺制药有限公司 深圳 |
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| 摘 要： | 利用硼鳌合物的方法,增大6—氟与7—氯取代活性的差异,使哌嗪化选择性取代收率达到82.3%。
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| 关 键 词： | 诺氟沙星 合成 硼鳌合物 |
Improvement of technological process for Synthesis of Norfloxacin |
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| Ji Genghao. Improvement of technological process for Synthesis of Norfloxacin[J]. Chinese Journal of Modern Applied Pharmacy, 1991, (4): 14-15. |
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| Authors: | Ji Genghao |
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| Abstract: | Norfloxacin was prepared according to the Boric coordination complex method with mod ification. An available process starting from ethyl-1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate to Norfioxacin in 82.3% yield was described. |
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| Keywords: | Norfloxacin synthesis Boric coordination complex |
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