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Natural orifice transluminal endoscopic surgery (NOTES) for clinical management of intra‐abdominal diseases
Authors:Liu Liu  Philip W Y Chiu  Nagewasher Reddy  Khek‐Yu Ho  Seigo Kitano  Dong Wan Seo  Hisao Tajiri  APNOTES Working Group
Institution:1. Department of Surgery, Chinese University of Hong Kong, , Hong Kong, China;2. Asian Institute of Gastroenterology, , Hyderabad, India;3. Department of Gastroenterology and Hepatology, Yong Loo Lin School of Medicine, National University of Singapore, , Singapore;4. Department of Surgery I, Oita Medical University, , Oita;5. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, , Seoul, South Korea;6. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, , Tokyo, Japan
Abstract:Clinical research on natural orifice transluminal endoscopic surgery (NOTES) has been increasingly reported over the past 5 years and more than 1200 patients have received various NOTES procedures. The present article reviews the clinical practice of NOTES for the treatment of intra‐abdominal diseases, and was carried out through systematic search with specific keywords in major databases for NOTES‐related clinical literature. The last date of the search was 15 August, 2012. Transvaginal cholecystectomy is the commonest NOTES procedure reported, and its clinical feasibility and safety was established through prospective case series and randomized trials. There is a regional difference in NOTES development with the majority of NOTES fromCaucasian countries being transvaginal cholecystectomy and most reports from Asian countries being NOTES‐related procedures. Safe closure of gastrointestinal access remains challenging, and novel endoscopic instruments are essential to enhance future development of NOTES.
Keywords:natural orifice transluminal endoscopic surgery (NOTES)  transgastric endoscopic cholecystectomy  transgastric endoscopic peritoneoscopy  transvaginal endoscopic cholecystectomy
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