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Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT
Authors:Rakesh Malhotra  Timothy Craven  Walter T Ambrosius  Anthony A Killeen  William E Haley  Alfred K Cheung  Michel Chonchol  Mark Sarnak  Chirag R Parikh  Michael G Shlipak  Joachim H Ix
Institution:1. Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA;2. Imperial Valley Family Care Medical Group, El Centro, CA;3. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC;4. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN;5. Division of Nephrology, Department of Medicine, Mayo Clinic, Jacksonville, FL;6. Division of Nephrology & Hypertension, Department of Internal Medicine, University of Utah; Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT;7. Division of Nephrology & Hypertension, Department of Medicine, University of Colorado, Denver, CO;8. Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA;9. Division of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT;10. Division of General Internal Medicine, San Francisco VA Medical Center, San Francisco, CA;11. Kidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, CA;12. Division of Preventive Medicine, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA;13. Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA
Abstract:
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  • Keywords:Chronic kidney disease (CKD)  hemodynamics  blood pressure (BP)  hypertension  urinary biomarkers  CKD progression  intensive BP control  kidney tubule cell  tubular injury  urine  estimated glomerular filtration rate (eGFR)  eGFR decline  renal perfusion
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