Ultraviolet A1 phototherapy for mycosis fungoides |
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| Authors: | K. Olek‐Hrab W. Silny A. Dańczak‐Pazdrowska A. Osmola‐Mańkowska P. A. Sadowska A. Polańska R. Gniadecki D. Jenerowicz |
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| Affiliation: | 1. 1Department of Dermatology, Poznan Medical University of Sciences, Poznan, Poland;2. Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark |
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| Abstract: | Background. Mycosis fungoides (MF) is the most common form of primary cutaneous lymphoma, and is characterized by a malignant proliferation of CD4+ cells. Psoralen ultraviolet A (PUVA) irradiation is the most common treatment for cutaneous lesions. However, PUVA carries the risk of adverse reactions to psoralens and long‐term risk of skin cancer. UVA1 may be a safer alternative. Aim. To assess the efficacy of UVA1 phototherapy in patients with early‐stage MF (T1–T2). Methods. Four patients with early‐stage MF were treated with 1630–2710 J/cm2 UVA1 given in 29–40 fractions, and the effect was assessed by clinical examination and by high‐resolution ultrasonography. Results. Complete clinical remission of MF was achieved in all cases. Conclusions. This preliminary report indicates that UVA1 phototherapy might be an efficient treatment for early‐stage MF. |
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