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Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupilone
Authors:T Ebenhan  M Honer  SM Ametamey  PA Schubiger  M Becquet  S Ferretti  C Cannet  M Rausch  PMJ McSheehy
Institution:(1) Global Imaging Group, Novartis Institute of Biomedical Research, 4002 Basel, Switzerland;(2) Animal Imaging Center-PET, Center for Radiopharmaceutical Science, Eidgenoessische Technische Hochschule (ETH) Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland;(3) Oncology Research, Novartis Institute of Biomedical Research, 4002 Basel, Switzerland;
Abstract:

Purpose  

The suitability of 18F]FDG, 18F]FLT, 18F]FET, and 18F]FCH as non-invasive positron emission tomography (PET) biomarkers for monitoring response to chemotherapy was analyzed in various experimental tumor models.
Keywords:
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