Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupilone |
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Authors: | T Ebenhan M Honer SM Ametamey PA Schubiger M Becquet S Ferretti C Cannet M Rausch PMJ McSheehy |
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Institution: | (1) Global Imaging Group, Novartis Institute of Biomedical Research, 4002 Basel, Switzerland;(2) Animal Imaging Center-PET, Center for Radiopharmaceutical Science, Eidgenoessische Technische Hochschule (ETH) Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland;(3) Oncology Research, Novartis Institute of Biomedical Research, 4002 Basel, Switzerland; |
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Abstract: | Purpose The suitability of 18F]FDG, 18F]FLT, 18F]FET, and 18F]FCH as non-invasive positron emission tomography (PET) biomarkers for monitoring response to chemotherapy was analyzed in
various experimental tumor models. |
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