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| 引用本文： | 袁尉力,王绪凯.???????????????????????????????????????о????[J].中国实用口腔科杂志,2012,5(2):116-119. |
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| 作者姓名： | 袁尉力 王绪凯 |
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| 作者单位： | ?й?????????????????????????? 110002 |
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| 基金项目： | 辽宁省教育厅课题（2009A747） |
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| 摘 要： | 目前，普萘洛尔已成为复杂严重婴幼儿血管瘤的一线治疗选择，但其究竟是通过何种机制治疗婴幼儿血管瘤仍然没有一个普遍接受的观点。本文对目前国内外关于普萘洛尔治疗血管瘤的分子生物学机制及其临床研究做一综述，以期为临床使用普萘洛尔治疗婴幼儿血管瘤提供有价值的线索和启示。
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| 关 键 词： | ??????? ????? ????????????? ??????? |
| 收稿时间： | 2011-10-27 |
| 修稿时间： | 2011-12-29 |
The molecular mechanism of propranolol treatment for hemangioma and its clinical application progress |
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| YUAN Wei-li,WANG Xu-kai.The molecular mechanism of propranolol treatment for hemangioma and its clinical application progress[J].chinese Journal of Practical Stomatology,2012,5(2):116-119. |
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| Authors: | YUAN Wei-li WANG Xu-kai |
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| Institution: | . Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical Uni- versity, Shenyang 110002, China |
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| Abstract: | Oral propranolol has become a very recent first-line treatment option for complicated and severe infantile hem- angioma with impressive efficacy and generally good tolerance. However, the effects of propranolol on infantile hemangio- ma were discovered by chance, and very little is known about its mechanisms of action in infantile hemangioma. Here we present a summary of current knowledge of how propranolol interferes with endothelial cells, vascular tone, angiogenesis and apoptosis and the clinical application progress of propranolol treatment for hemangioma. We hope that this review can provide valuable clues and inspiration for clinical application of propranolol treatment for hemangioma. |
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| Keywords: | propranolol hemangioma molecular mechanism drug therapy |
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