HIV合并隐孢子虫感染及影响因素分析

目的 目的 了解HIV合并隐孢子虫感染情况及其影响因素。 方法 方法 对安徽省阜阳市309名HIV感染者粪便样本进行检测, 以确定其隐孢子虫感染情况, 并对研究对象进行问卷调查和血清学检测。采用单因素分析和多因素Logistic回归模型对合并感染的影响因素进行分析。结果 结果 共粪检302人, 隐孢子虫感染率为8.28%, 男性 （13.49%） 显著高于女性（2.92%）, 差异有统计学意义 （P < 0.05）。多因素分析表明, 男性(OR = 6.700, 95% CI: 2.030, 22.114）, 年龄< 42岁 （OR = 4.148, 95%CI: 1.348,12.761）, 体内IL?2水平< 77 pg/ml (OR = 0.226, 95%CI: 0.076, 0.674), 个人卫生习惯与合并隐孢子虫感染有关(OR = 0.324, 95%CI: 0.105, 0.994)。结论 结论 HIV合并隐孢子虫感染率高, 男性、 年龄< 42岁、 体内IL?2水平较高以及个人卫生习惯较差的HIV感染者应作为隐孢子虫感染的重点防治对象。

Cross-section study on co-infection of HIV and Cryptosporidium

Objective To investigate the co-infection status of HIV and Cryptosporidium, and explore the influencing factors associated with the co-infection. Methods A total of 309 people with HIV positive in Fuyang City of Anhui Province were recruited and their fecal and blood samples were collected for examinations of Cryptosporidium spp. infection and the levels of hemoglobin, cytokines and CD4+/CD8+ T-lymphocytes. Meanwhile, the questionnaire survey was conducted. Results Among 302 people involved in fecal examinations, the infection rate of Cryptosporidium spp. was 8.28%, and the difference between infection rates of the male (13.49%) and the female (2.92%) was statistically significant (P < 0.05). The multivariate logistic regression model showed that 4 factors were significantly associated with the coinfection of HIV and Cryptosporidium spp, including male (OR =6.700, 95% CI: 2.030, 22.114), younger than 42 years old (OR = 4.148, 95% CI: 1.348, 12.761), level of IL-2 below 77 pg/ml (OR =0.226, 95%CI: 0.076, 0.674) and personal hygiene habits (OR = 0.324, 95% CI: 0.105, 0.994). Conclusion The co-infection rate of Cryptosporidium spp. and HIV is high, the key targets of control are the people who are male, younger than 42 years old, with high level of IL2 and poor personal hygiene habits.