| 高效液相色谱法测定清脑降压片中黄芩苷含量 |
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| 引用本文： | 张志成.高效液相色谱法测定清脑降压片中黄芩苷含量[J].中国药业,2009,18(18):33-34. |
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| 作者姓名： | 张志成 |
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| 作者单位： | 青海省海西州药品检验所,青海,德令哈,817000 |
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| 摘 要： | 目的采用高效液相色谱（HPLC）法测定清脑降压片中的黄芩苷含量。方法以Zorbax Eciipse XDB-8 C18（250mm×4.6mm，5μm）为分析柱，以甲醇-水-磷酸（45：55：0.2）为流动相，流速1.0mL／min，检测波长280nm。结果黄芩苷进样量在0.312-1.560μg范围内与峰面积线性关系良好（r=0.9999），平均回收率为97.51％，RSD=1.03％（n=5）。结论HPLC法可用于清脑降压片的质量控制。
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| 关 键 词： | 高效液相色谱法 清脑降压片 黄芩苷 含量测定 |
Determination of Baicalin in Qingnao Antihypertensive Tablets by HPLC |
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| Zhang Zhicheng.Determination of Baicalin in Qingnao Antihypertensive Tablets by HPLC[J].China Pharmaceuticals,2009,18(18):33-34. |
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| Authors: | Zhang Zhicheng |
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| Institution: | Zhang Zhicheng(Haixi Prefecture Institute for Drug Control, Delingha, Qinghai, China 817000) |
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| Abstract: | Objective To establish a HPLC method for the determination of baicalin in Qingnao Antihypertensive Tablets. Methods The Zorbax Eciipse XDB-C18 column（250mm×4.6mm,5μm）was used with methanol-water-phosphoric acid（45：55：0.2）as the mobile phase, the flow rate was 1.0 mL/min,the detection wavelength was 280 nm. Results The linear range of baicalin was 0.312-1.560μg（r=0.9999）, the average recovery rate was 97.51%, RSD=1.03%（n=5）. Conclusion The method can be used to determine the content of baicalin in Qingnao Antihypertensive Tablets. |
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| Keywords: | HPLC Qingnao Antihypertensive Tablets baicalin content determination |
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