圆窗置管微泵灌注地塞米松治疗难治性突发性感音神经性聋

目的：观察圆窗内置管微泵灌注地塞米松治疗难治性突发性感音神经性聋（突聋）的疗效。方法：13例常规方法治疗4．8周无效的突聋患者，作外耳道皮瓣，圆窗置管经微泵灌注地塞米松，每次2．5mg，维持1h，每天2次，连续给药1周。用药期间观察记录听力改变、耳鸣和眩晕等情况。结果：13例患者治疗完成后1个月纯音测听检查：显效2例，0．25～4．00kHz听阈平均提高30．5dB；有效3例，平均提高16．7dB,无效8例，有效率38．5％（5／13）。结论：圆窗置管微泵灌注地塞米松治疗突聋的方法，能保证药物持续泵入和高浓度作用于内耳，优于鼓膜穿刺注药；操作稍复杂，但创伤小，耗费不高，为常规方法治疗无效的突聋患者提供了再次治疗获效的机会。

Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss

Objective:To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss (SSNHL).Method:Dexamethasone (2.5 mg) was perfused transtympanically through round window catheter by Micro-infusion pump. The perfusion was taken twice a day and continued for an hour each time, for a total of 7 days.Result:Thirteen patients have been followed up for 1 month. Five of them (38.5%) were demonstrated a 17~54 dB improvement in pure-tone threshold average (PTA). The other 8 patients (61.5%) had no effect.Conclusion:Round window catheter placement with dexamethasone perfusion is a cost-effective and useful treatment for SSNHL patients who had no effect through conventional therapy, although hearing thresholds of these patients had hardly improved to normal levels.