高血压危象CEC、血液流变性变化的意义

目的 :探讨循环内皮细胞 ( CEC)、血液流变性在高血压危象形成中的作用及相互关系。方法 :对 2 2例高血压危象患者、 2 8例高血压病患者和 2 2例正常人 ,以 Percoll密度梯度法分离计数 CEC,并测定切变率为 2 3 0 s- 1及 10 s- 1下的全血粘度。结果 :高血压危象组CEC,ηb均显著高于高血压病组 ,同时亦显著高于正常组。相关分析表明 ,高血压危象组及高血压病组中 ,CEC与ηb( 2 3 0 s- 1 )、ηb( 10 s- 1 )呈正相关关系。结论 :CEC增多及血粘度增高是高血压病和高血压危象形成的重要原因。

Observation of CEC and Hemorheological Indexes in Patients with Hypertensive Crisis

Objective: To make an inquiry into the performance and interaction of CEC and hemorheology in forming of hypertensive crisis(HC). Methods: CEC was detected by Percoll density gradient method in 22 patients with HC, 28 patients with hypertension and 22 healthy person. The whole blood viscosity [ηb(230 s -1 ), ηb(10 s -1 )] was also measured. Results: CEC and whole blood viscosity in patients with HC were significantly higher than that in patients with hypertension and normal person. Corrective analysis revealed that CEC positively correlated with ηb(230 s -1 ) and ηb(10 s -1 ) in patients with HC, so did it in patients with hypertensive. Conclusion: Increased CEC and high blood viscosity were important factors of hypertension and HC.