| 埃索美拉唑治疗胃食管反流病的系统评价 |
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| 引用本文： | 钟利春,贾红,李昌平,邹义君.埃索美拉唑治疗胃食管反流病的系统评价[J].中国临床药理学与治疗学,2006,11(10):1154-1159. |
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| 作者姓名： | 钟利春 贾红 李昌平 邹义君 |
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| 作者单位： | 1. 泸州医学院附属医院消化内科,泸州,646000,四川
2. 泸州医学院公共卫生学院,泸州,646000,四川 |
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| 摘 要： | 目的：评价埃索美拉唑与其它质子泵抑制剂（PPI）比较治疗胃食管反流病的疗效。方法：文献检索并收集埃索美拉唑与其它PPI相比较的随机对照试验文献，按Cochrane协作网提供的方法对纳入文献进行质量评价。结果：共纳入14个随机对照研究（RCT）。对于非糜烂性食管炎埃索美拉唑与潘索拉唑比较在6个月后症状缓解率差异有统计学意义。对于糜烂性食管炎，埃索美拉唑与其他PPI比较均有统计学意义。结论：对于非糜烂性食管炎，埃索美拉唑比潘索拉唑疗效好；对于糜烂性食管炎，埃索美拉唑比其他PPI疗效好。
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| 关 键 词： | 埃索美拉唑 胃食管反流病 系统评价 Meta分析 |
| 文章编号： | 1009-2501(2006)10-1154-06 |
| 收稿时间： | 04 26 2006 12:00AM |
| 修稿时间： | 06 8 2006 12:00AM |
Esomeprazole for gastroesephageal reflux disease: a systematic review |
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| ZHONG Li-chun,JIA Hong,LI Chang-ping,ZHOU Yi-jun.Esomeprazole for gastroesephageal reflux disease: a systematic review[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2006,11(10):1154-1159. |
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| Authors: | ZHONG Li-chun JIA Hong LI Chang-ping ZHOU Yi-jun |
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| Affiliation: | 1.Department of Gastroenterology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan , China ; 2.Department of Public Health, Luzhou Medical College, Luzhou 646000, Sichuan , China |
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| Abstract: | AIM:To evaluate the efficacy of esomeprazole in the treatment of gastroesephageal reflux disease (GERD) when compared to the other PPI. METHODS:We were searching RCT researchers contacted. The quality evaluation of studies and data analysis were conducted by the methods of the Cochrane Collaboration. RESULTS:Fourteen RCTs met the inclusion criteria. In patients with NERD symptom relief rate esomeprazole had significant effect when compared with pantoprazole. In patients with EE symptom relief rate esomeprazole had significant effect comparing with the other PPI. CONCLUSION:Esomeprazole was better than pantoprazole in patients with NERD symptom relief rate. In patients with EE symptom relief rate esomeprazole was better than the other PPI. |
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| Keywords: | esomeprazole gastroesephageal reflux disease systematic review Meta-analysis |
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