非囊性纤维化支气管扩张治疗进展

非囊性纤维化支气管扩张是慢性气道破坏性疾病,其可造成严重的社会经济负担.近年来,随着诊疗技术尤其是高分辨率CT的应用,支气管扩张症的早期诊断率随之提高,但治疗效果仍不尽如人意.非囊性纤维化支气管扩张的病理生理基础为持续存在的病原微生物的定植、感染、气道损伤的恶性循环.在治疗方面尤其是高效、不良反应小的吸入性抗生素的地位越来越凸显.本文就非囊性纤维化支气管扩张症的病理、病因以及治疗策略的进展作一综述.

Treatment advances of non-cystic fibrosis bronchiectasis

Non-cystic fibrosis bronchiectasis is a chronic airway destructive disease.The associated social and economic cost is heavy.Because high-resolution computed tomography scanning is more commonly used nowadays,bronchiectasis is diagnosed at earlier stage,but the treatment result is unsatisfied.Pathologically,a vicious cycle of infection and inflammation exists in the permanently damaged airways.Lately inhaled prolonged antibiotic is becoming especially prominent due to its high efficacy and small adverse effects.This article reviews the pathology,aetiology and management strategies of non-cystic fibrosis bronchiectasis.