磷酸肌酸在产程中的应用

目的 探讨磷酸肌酸在产程中改善胎儿缺氧的应用价值。方法 选择2012年7月至2013年9月之间石家庄市第一医院产科收治的692例孕足月分娩第一产程中胎心监护提示无反应型的孕妇，随机分为观察组和对照组。对照组孕妇给予5％葡萄糖和维生素C治疗；观察组的孕妇给予5％葡萄糖和磷酸肌酸钠治疗。观察两组治疗效果及分娩结局。结果 观察组治疗后显效率和总有效率均显著高于对照组（χ^2分别为12．220、38．853，均P＜0．05），观察组胎儿窘迫、新生儿轻度窒息和剖宫产率均显著低于对照组（χ^2分别为20．568、9．213、13．106，均P＜0．05），而两组新生儿重度窒息发生率无显著性差异（χ^2=1．000， P＞0．05）。结论 磷酸肌酸在产程中改善胎儿轻度缺氧具有较好的临床应用价值。

Application of creatine phosphate in course of childbirth

Objective To investigate the clinical value of creatine phosphate （CP） in the treatment of fetal hypoxia. Methods From July 2012 to September 2013, 692 pregnant women without response to fetal heart monitoring at the first stage were admitted in the First Hospital of Shijiazhuang City, and they were randomly divided into observation group and control group. The control group was treated by 5% glucose and vitamin C, while the observation group was treated by 5% glucose and CP. The curative effect and childbirth outcomes were observed in two groups. Results The significantly effective rate and total effective rate in the observation group were significantly higher than those in the control group （X^2 value was 12.220 and 38. 853, respectively, both P 〈 0. 05）. The incidence of fetal distress, mild fetal asphyxia and caesarean section was significantly lower in the observation group than in the control group （X^2 value was 20.568, 9.213, and 13. 106, respectively, all P 〈0.05）, but there was no significant difference in the incidence of severe fetal asphyxia between two groups （X^2 = 1. 000, P 〉 0.05）. Conclusion CP has notable curative effect on the treatment of mild fetal hypoxia.