Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons |
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| Authors: | F Grassi H D Lux |
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| Affiliation: | Department of Neurophysiology, Max Planck Institute for Psychiatry, Martinsried, F.R.G. |
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| Abstract: | Externally applied gamma-aminobutyric acid (GABA) quickly and reversibly reduces by 60% voltage activated Ca2+ currents in chick dorsal root ganglion cells. This action is antagonized by depolarization, with characteristic time and voltage requirements. Intracellular perfusion with guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) or guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) mimicks and blocks the GABA effect, respectively. A 3-state model describing the reactions involved is proposed. |
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