A newly discovered Fc receptor that explains IgG-isotype disparities in effector responses |
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| Authors: | Bolland Silvia |
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| Affiliation: | Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive 217, Rockville, Maryland 20852, USA. |
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| Abstract: | The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. A novel FcgammaR that binds IgG2 but not IgG1 has just been identified, potentially explaining differences in biological activity that are seen with various IgG isotypes. |
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