| 肾炎灵冲剂对家兔慢性肾小球肾炎的作用 |
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| 引用本文： | 崔树勋,李吉平,王秋静,杨世杰.肾炎灵冲剂对家兔慢性肾小球肾炎的作用[J].吉林大学学报(医学版),2000,26(6):589-591. |
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| 作者姓名： | 崔树勋 李吉平 王秋静 杨世杰 |
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| 作者单位： | 基础医学院药理教研室 吉林 长春 130021 |
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| 摘 要： | 目的 :观察肾炎灵冲剂对家兔慢性肾小球肾炎的作用。方法 :用大鼠肾小球基底膜和弗氏佐剂 ,给家兔注射 ,复制出慢性肾小球肾炎模型。给肾炎灵冲剂 ,观察尿蛋白、血清尿素氮、肌酐、血清白蛋白、球蛋白及肾组织的病理学改变。结果 :肾炎灵冲剂可剂量依赖性地降低尿蛋白(P<0 .0 5)、血清尿素氮 (P<0 .0 5)、肌酐 (P<0 .0 5)的水平 ,提高血清白蛋白的水平 (P<0 .0 5) ,减轻肾小球病变。结论 :肾炎灵冲剂对家兔慢性肾小球肾炎具有保护作用
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| 关 键 词： | Steblay肾小球肾炎 肾炎灵冲剂 家兔 |
| 文章编号： | 0253－3707(2000)06－0589－03 |
| 修稿时间： | 1999年7月5日 |
Effects of Shenyanling on chronic glomerulonephritis in rabbits |
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| Cui Shuxun,Li Jiping,WANG Qiujing,Yang Shijie.Effects of Shenyanling on chronic glomerulonephritis in rabbits[J].Journal of Jilin University: Med Ed,2000,26(6):589-591. |
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| Authors: | Cui Shuxun Li Jiping WANG Qiujing Yang Shijie |
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| Abstract: | Objective :To sutdy the effects of Shenyanling on chronic glomerulonephritis in rabbits. Meth-ods:Rat glomerular base membrane (GBM) and Freund＇s adjuvant were injected into rabbits subcuta-neously or intracutaneously to build the Steblay nephritis model. Shenyanglin was administered. Kidneyfunction was evaluated by measuring urine protein,urea nitrogen ,creatinine ,albumin and globulin in serumas wellas the histopathological changes of kidney were observed. Results:Compared with model group,Shenyanling could dose-dependently reduce the level of the urine protein,urea nitrogen and creatinine inserum and the damage of kidney;while,the serum albumin could maintain the normal level (P＜0.05).Conclusion:Shenyanling has protective effects on chronic glomerulonephritis in rabbits. |
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| Keywords: | Steblay nephritis Shenyanling rabbit |
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