乳腺癌保留乳头乳晕成型术的临床病理研究

目的 :为保留乳头乳晕的乳腺癌成型术提供临床病理基础。方法 :采用临床资料的分析与病理相结合的方法、将乳腺癌患者的乳头和乳晕整体标本连续切片病理检查。用流式细胞技术进行癌组织DNA倍体分析、免疫组化法增殖细胞核抗原 (PCNA)含量测定。进一步分析乳腺癌患者保留乳头和乳晕的安全性和可能性。为乳腺成型提供实践依据。结果 :检测肿瘤至乳晕的平均距离为 1 9.6毫米 ,侵犯乳头乳晕共 5例 ,其中Ⅲb 3例、Ⅳ期 2例。这 5例DNA倍体均为异倍体。PCNA阳性 50 %～ 75 %及 >75 %占Ⅲ、Ⅳ期乳腺癌的 77.78%。结论 :乳晕旁1 .96厘米以外的乳房肿瘤有保留乳房的适应证 ,肿瘤位于乳晕下方、临床分期Ⅲ期及Ⅳ期无保留乳房的适应证。严格掌握保留乳头乳晕的适应证条件 ,乳腺癌保留乳房成型术才能更加安全

The clinical and pathological study in moulding operation about breast cancer

Purpose:We shall provide the clinical and pathological bases in breast cancer operation in which the nipple and ring reserved.Methods:We combine clinical and pathological material , analyses the result of the nipple and ring that cut off wholly and the sample cut down in slice continuously. We analysis the DNA polyploid of carcinoma tissue in FCM technology . Sinonimously , we measure the PCNA expression in immunohistochemistory. We reserve the breast of patients that suffer from breast cancer and further discuss the possibility and safely .The study will provide practice evidence for breast cancer patients who would perform operation. Results:We measure the linear distance from edge of tumor to ring that are 19.6mm. and The patient suffer from breast cacinoma in stage and tumor bed under nipple and ring could not perform operation that reserved nipple and ring.Conclusions:If we stringent control the standard in reservation of breast, The patients suffering from breast cancer will be safely more and more.