| VIP-cAMP-PKA-AQP3信号通路与肺肠合治法治疗支气管哮喘的研究进展 |
| |
| 引用本文： | 惠毅,闫曙光,郑旭锐,史捷,李京涛,单宇鹏. VIP-cAMP-PKA-AQP3信号通路与肺肠合治法治疗支气管哮喘的研究进展[J]. 中国中医基础医学杂志, 2019, 0(8): 1168-1170 |
| |
| 作者姓名： | 惠毅 闫曙光 郑旭锐 史捷 李京涛 单宇鹏 |
| |
| 作者单位： | 陕西中医药大学;陕西中医药大学附属医院;空军军医大学唐都医院肿瘤科 |
| |
| 基金项目： | 国家自然科学基金资助项目(81703974)-从VIP-cAMP-PKA-AQP3信号通路研究肺肠合治法治疗支气管哮喘的分子机制;陕西省科技厅项目(2014JQ4147)-从ERK/α-SMA研究宣白承气汤对哮喘大鼠气道重构的影响 |
| |
| 摘 要： | 肺肠合治法是中医临床治疗支气管哮喘的常用方法之一,中医的肺和大肠属于功能概念,包涵西医学的肺和大肠,两脏在功能上相互联系,在治疗上相互为用,从系统生物学的角度,两者之间应当存在着共同的物质基础和相关的信号传导通路,但目前尚不十分清楚。文献研究表明,VIP-cAMP-PKA-AQP3信号通路既参与支气管哮喘(肺病)的发病,又在功能性便秘(肠病)的发病机制中发挥重要作用,VIP和AQP3既是治疗支气管哮喘的重要靶点,又是通肠泻下法治疗功能性便秘的作用靶点,这一结果提示该信号通路可能是肺与大肠之间相互联系的物质基础。本文以该通路为切入点,分析其在哮喘发病中的作用以及肺肠合治法对该通路的影响,以期为哮喘的治疗提供新的靶点。
|
| 关 键 词： | 支气管哮喘 肺肠合治法 VIP-cAMP-PKA-AQP3信号通路 |
Research Progress of VIP-cAMP-PKA-AQP3 Signal Path and Treating Bronchial Asthma by The Treating Lung and Large Intestine Simultaneously |
| |
| HUI Yi,YAN Shu-guang,ZHENG Xu-rui,SHI Jie,LI Jing-tao,SHAN Yu-peng. Research Progress of VIP-cAMP-PKA-AQP3 Signal Path and Treating Bronchial Asthma by The Treating Lung and Large Intestine Simultaneously[J]. Chinese Journal of Basic Medicine In Traditional Chinese Medicine, 2019, 0(8): 1168-1170 |
| |
| Authors: | HUI Yi YAN Shu-guang ZHENG Xu-rui SHI Jie LI Jing-tao SHAN Yu-peng |
| |
| Affiliation: | (Shaanxi university of Chinese Medicine, Shaanxi Xianyang 712046, China;Teaching Hospital of shannxi university of TCM,Shaanxi Xianyang 712000, China;Department of Oncology, Tangdu Hospital Affiliated to Air Force Military Medical University , Xi'an 710038, China) |
| |
| Abstract: | HUI Yi;YAN Shu-guang;ZHENG Xu-rui;SHI Jie;LI Jing-tao;SHAN Yu-peng(Shaanxi university of Chinese Medicine, Shaanxi Xianyang 712046, China;Teaching Hospital of shannxi university of TCM,Shaanxi Xianyang 712000, China;Department of Oncology, Tangdu Hospital Affiliated to Air Force Military Medical University , Xi'an 710038, China) |
| |
| Keywords: | Bronchial asthma Treating Lung and Large Intestine simultaneously VIP-cAMP-PKA-AQP3 signaling pathway |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
