| HO-1基因启动子区多态性与客家人群糖尿病个体冠心病患病风险关联 |
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| 引用本文： | 黎剑泉,朱德兴,刘丽娜,陈宋明,李玉华. HO-1基因启动子区多态性与客家人群糖尿病个体冠心病患病风险关联[J]. 临床心血管病杂志, 2011, 27(2): 147-151 |
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| 作者姓名： | 黎剑泉 朱德兴 刘丽娜 陈宋明 李玉华 |
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| 作者单位： | 1. 梅州市丰顺县人民医院心内科,广东梅州,514300
2. 汕头大学医学院第一附属医院心内科 |
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| 基金项目： | 广东省梅州市科委基金资助项目(No:2008B43) |
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| 摘 要： | 目的:通过检测客家人群冠心病患者HO-1基因启动子区GT重复多态性,旨在阐明HO-1基因多态性与冠心病易感性的关联.方法:选择广东梅州客家地区确诊的冠心病患者100例为病例组,经冠状动脉造影或无创检查排除冠心病的个体100例为对照组.采用荧光标记PCR和毛细管电泳相结合技术检测HO-1启动子区(GT)n多态性并进行基因...
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| 关 键 词： | 冠状动脉疾病 血红素氧化酶-1 基因多态性 糖尿病 |
A polymorphism in HO-1 gene promoter increases risk for coronary artery disease and KeJia population |
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| LI Jianquan,ZHU Dexing,LIU Lina,CHEN Songming,LI Yuhua. A polymorphism in HO-1 gene promoter increases risk for coronary artery disease and KeJia population[J]. Journal of Clinical Cardiology, 2011, 27(2): 147-151 |
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| Authors: | LI Jianquan ZHU Dexing LIU Lina CHEN Songming LI Yuhua |
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| Affiliation: | LI Jianquan1 ZHU Dexing1 LIU Lina1 CHEN Songming2 LI Yuhua2(1Department of Cardiology,Fengshun County People's Hospital,Meizhou,514300,China,2Department of Cardiology,the First Affiliated Hospital,Medical College,Shantou University) |
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| Abstract: | Objective:This study is designed to investigate the relationship between short tandem repeat(STR) polymorphism in Heme oxygenase-1(HO-1) gene promoter and susceptibility of CAD in Ke-jia population,contributes to provide a new strategy for prevention and treatment of CAD by using HO-1 for this population.Method:A total of 100 patients who were diagnosed as having CADs were selected in this study,another 100 subjects who were without evidence of CADs with their sex and age similar to CAD patients were select... |
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| Keywords: | coronary artery disease heme oxygenase-1 gene polymorphism diabetes |
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