返流性食管炎并上消化道出血临床分析

目的探讨返流性食管炎(RE)并上消化道出血的发病机制和治疗方案的选择.方法对30例RE并上消化道出血进行临床观察.针对其发病机制并采用洛赛克40 mg 5%葡萄糖(或生理盐水)250 ml静滴,2次/d,共5 d.止血后予以洛赛克 莫沙必利维持治疗观察止血效果和对RE治疗效果.结果洛赛克治疗上消化道出血显效80%,总有效率96.7%(P＜0.01).对RE食管粘膜病损有显著治疗效果(P＜0.05).结论各种原因导致返流物造成食管粘膜损伤为RE发病基础.洛赛克可作为RE并上消化道出血的一线治疗药物.

Clinical analysis of reflux esophagitis complicated with gastrointestinal bleeding

Aim Discuss the etiology and the treatment of reflux esophagitis complicated with upper gastrointestinal bleeding.Methods We clinically observed 30 cases of patients suffering from upper gastrointestinal bleeding who were given 40 mg losec twice daily intravenously for 5 continous days, then losec and misopride orally to maintain therapeutic effect after bleeding ended.Results Losec could significantly improve esophageal mucosal lesion caused by reflux esophagitis ( P <0 05)) as we saw significant improvements among 80% patients and apparent improvements with 96 7% patients ( P <0 01).Conclusion The etiological basis of reflux esophagitis is esophageal mucosal lesion caused by esophageal reflux.losec can be first line therapeutic agent to treat reflux esophagitis complicated with upper gastrointestinal bleeding.