Polypeptide profile of HBSAg excreted by a human hepatoma cell line. |
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| Authors: | J Monjardino E Crawford |
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| Affiliation: | 1. Division of Cell Studies, Clinical Sciences Building, The Royal Free Hospital, Pond Street, London NW3 2QG, England;2. Department of Medicine, The Royal Free Hospital, Pond Street, London NW3 2QG, England |
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| Abstract: | In this study the polypeptide composition of HBsAg particles secreted by a human hepatoma cell line (Alexander) was analysed. Five major components were identified with molecular weights of 22,000, 28,000, 33,000, 38,000, and 49,000. The two smaller species (MW 22,000 and 28,000) were found to be the major components. The polypeptide profile is similar to that described for HBsAg derived from sera of acute hepatitis patients and of chronic carriers. Data are also presented suggesting that the various HBsAg polypeptide components are aggregates and glycosylated derivatives of the 22,000 MW polypeptide subunit. |
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| Keywords: | To whom reprint requests should be addressed. |
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