| 灯盏花素壳聚糖-海藻酸钠微囊的制备与释药机制考察 |
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| 引用本文： | 张彦青,张明春,解军波,戚务勤. 灯盏花素壳聚糖-海藻酸钠微囊的制备与释药机制考察[J]. 时珍国医国药, 2007, 18(8): 1975-1976 |
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| 作者姓名： | 张彦青 张明春 解军波 戚务勤 |
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| 作者单位： | 1. 天津商学院,天津,300134;北京大学药学院,北京,100083
2. 天津商学院,天津,300134 |
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| 摘 要： | 目的考察灯盏花素壳聚糖-海藻酸钠微囊的制备工艺和释药机制。方法采用复凝聚法制备了灯盏花素壳聚糖-海藻酸钠微囊。采用常用模型拟合探讨其药物释放机制。结果所得微囊的制备工艺简单,大小均匀,载药量大且药物含量均匀。结论利用复凝聚法制备灯盏花素海藻酸钙微囊方法简单,药物释放机制为骨架溶蚀作用。
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| 关 键 词： | 灯盏花素 制备工艺 壳聚糖-海藻酸钠微囊 释药机制 |
| 文章编号： | 1008-0805（2007）08-1975-02 |
| 收稿时间： | 2006-11-28 |
| 修稿时间： | 2006-11-282007-03-27 |
Studies on the Preparation Technology and Drug Release Mechanism of Breviscapine Chitosan - alginate Microcapsules |
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| ZHANG Yan-qing,ZHANG Ming-chun,XIE Jun-bo,QI Wu-qin. Studies on the Preparation Technology and Drug Release Mechanism of Breviscapine Chitosan - alginate Microcapsules[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(8): 1975-1976 |
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| Authors: | ZHANG Yan-qing ZHANG Ming-chun XIE Jun-bo QI Wu-qin |
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| Abstract: | Objective To investigate the preparation technology and the drug release mechanism of Breviscapine chitosan-alginate microcapsules.Methods Breviscapine chitosan-alginate microcapsules were prepared by coacervation technology.Model-fitting were used to study the release mechanism of Breviscapine from the microcapsules.Results Prepared Breviscapine chitosan-alginate microcapsules has such advantages as simple technology,uniformity in diameters and drug loading.Conclusion The preparation procedure is simple.And the release of Breviscapine can be described as matrix erosion. |
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| Keywords: | Breviscapine Preparation technology Chitosan-alginate microcapsules Release mechanism |
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