| 4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3,3-二苯基)丙酯盐酸盐在小鼠的抗肿瘤作用 |
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| 引用本文： | 郭维,冉福香,王瑞卿,崔景荣,李润涛,程铁明,葛泽梅.4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3,3-二苯基)丙酯盐酸盐在小鼠的抗肿瘤作用[J].中国临床药理学与治疗学,2004,9(1):59-62. |
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| 作者姓名： | 郭维 冉福香 王瑞卿 崔景荣 李润涛 程铁明 葛泽梅 |
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| 作者单位： | 1. 北京大学天然药物及仿生药物国家重点实验室,北京,100083
2. 北京大学药学院化学生物学系,北京,100083 |
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| 基金项目： | 国家自然基金资助项目 (№ 2 0 172 0 0 6)，国家重点科技项目 (№ 96 90 1 0 2 0 8) |
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| 摘 要： | 目的 :观察 4 甲基哌嗪 1 二硫代甲酸 (3 氰基 3,3 二苯基 )丙酯盐酸盐 (Hyd)对小鼠移植性肿瘤的抑制作用 ,以确定该化合物的应用前景。方法 :采用小鼠肉瘤 180和肝癌 2 2及人胃癌异种移植裸鼠肿瘤模型 ,观察Hyd对小鼠移植性肿瘤生长的影响。结果 :通过口服灌胃给药 ,不同浓度Hyd对小鼠移植性肉瘤S180 抑制率可达到 4 6 .4 %～ 5 9.6 % (P <0 .0 1～ 0 .0 0 1) ;对小鼠移植性肝癌H2 2 抑制率可达到39 .3%～ 5 1.6 % (P <0 .0 5～ 0 .0 0 1) ;对裸鼠人胃癌异种移植瘤的抑制率可达到 18.1%～ 5 9.0 %。结论 :Hyd对小鼠移植性肝癌H2 2 和小鼠移植性肉瘤S180 有明显抑制作用 ,对人胃癌裸小鼠异种移植性肿瘤也有明显抑制作用
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| 关 键 词： | 4-甲基哌嗪-1-二硫代甲酸-(3-氰基-3 3-二苯基)丙酯盐酸盐 肉瘤S180 肝癌H22 人胃癌异种移植性肿瘤 |
| 文章编号： | 1009-2501(2004)01-0059-04 |
| 修稿时间： | 2003年7月2日 |
Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester |
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| GUO Wei,RAN Fu Xiang,WANG Rui Qing,CUI Jing Rong,LI Run Tao ,CHENG Tie Ming ,GE Ze Mei National Research Laboratory of Natural and Biomimetic Drugs,Beijing ,China.Antitumor effect of hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3, 3-diphenyl-propyl ester[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2004,9(1):59-62. |
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| Authors: | GUO Wei RAN Fu Xiang WANG Rui Qing CUI Jing Rong LI Run Tao CHENG Tie Ming GE Ze Mei National Research Laboratory of Natural and Biomimetic Drugs Beijing China |
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| Institution: | GUO Wei,RAN Fu Xiang,WANG Rui Qing,CUI Jing Rong,LI Run Tao 1,CHENG Tie Ming 1,GE Ze Mei 1 National Research Laboratory of Natural and Biomimetic Drugs,Beijing 100083,China, 1 Department of Chemical Biologz School of Pharmaceutic Sciences,Beijing Univiersity,Beijing 100083,China |
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| Abstract: | AIM: To study the inhibition effects of the hydrochloride 4 methyl piperazine 1 carbodithioc acid 3 cyano 3,3 diphenyl propyl ester (Hyd) on the growth of transplant carcinoma in mice. METHODS: The growth of tumor was observed by models of transplant tumor in mice. RESULTS: The inhibition rates of Hyd against tumor growth of S 180 and H 22 implanted human gastric carcinoma were 46.4 %- 59.6 %, 39.3 %- 51.6 % and 18.1 %- 59.0 %, respectively in nude mice. CONCLUSION: Hyd can inhibit the growth of transplanted hepatocyte carcinoma 22, sarcoma 180 in mice, and implanted human gastric carcinoma in mice and nude mice. |
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| Keywords: | hydrochloride 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3 3-diphenyl-propyl ester sarcoma 180 hepatocyte carcinoma 22 implanted human gastric carcinoma |
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