| 脑缺血后大脑皮质神经生长因子和脑源性神经营养因子的改变 |
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| 引用本文： | 曾兢,王廷华,张晓,米兰兰,高礼.脑缺血后大脑皮质神经生长因子和脑源性神经营养因子的改变[J].四川大学学报(医学版),2001,32(2):216-218. |
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| 作者姓名： | 曾兢 王廷华 张晓 米兰兰 高礼 |
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| 作者单位： | 1. 昆明医学院神经科学研究所,
2. Institute for Research on Neuroscience, Kunming Medical College, |
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| 基金项目： | 国家自然科学基金资助!(批准号 3 0 0 0 0 2 2 7) |
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| 摘 要： | 目的 探讨脑缺血后大脑皮质神经生长因子 (NGF)、脑源性神经营养因子 (BDNF)的变化。方法 采用免疫组织化学 ABC法观察 NGF和 BDNF的改变。结果 NGF、BDNF样免疫阳性反应物主要分布于大脑皮质第 3、5层的神经元。脑缺血 1小时后 ,NGF、BDNF在皮质神经元的表达明显增加。结论 NGF、BDNF与脑缺血后大脑皮质神经细胞的损伤修复有关。
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| 关 键 词： | 神经生长因子 脑源性神经营养因子 大脑皮质 脑缺血 |
| 修稿时间： | 2000年8月26日 |
The Change of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Neurons of Cerebral Cortex of Adult Rat Following Local Ischemia |
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| Zeng Jing,Wang Tinghua,Zhang Xiao,Mi Lanlan,Gao Li.The Change of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Neurons of Cerebral Cortex of Adult Rat Following Local Ischemia[J].Journal of West China University of Medical Sciences,2001,32(2):216-218. |
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| Authors: | Zeng Jing Wang Tinghua Zhang Xiao Mi Lanlan Gao Li |
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| Abstract: | Objective To acquire knowledge about the change of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in neurons of cerebral cortex of adult rat following local ischemia. Methods Using specific antiserums of NGF and BDNF by immunohistochemical ABC method. Results NGF like and BDNF like immunoreactions distributed mainly in the neurons of the third and fifth layers in cerebral cortex. After local ischemia, the average gray degrees of NGF and BDNF in neurons of cerebral cortex both decreased on the operated side more than on the un operated side. Conclusion This experiment demonstrated that the levels of NGF and BDNF in neurons of cerebral cortex following ischemia were upregulated apparently, suggesting that NGF and BDNF may play an important role in the process of neurons' reaction after ischemia. |
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| Keywords: | Nerve growth factor Brain derived neurotrophic factor Cerebral cortex Ischemia |
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