V{beta}-specific immunotoxin selectively kills acetylcholine receptor-reactive T lymphocytes from mice with experimental autoimmune myasthenia gravis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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V{beta}-specific immunotoxin selectively kills acetylcholine receptor-reactive T lymphocytes from mice with experimental autoimmune myasthenia gravis

Authors:	Thompson Patricia A; McAtee Robert; Infante Anthony J; Currier Patricia; Beninati William; Krolick Keith A

Institution:	¹ Departments of Microbiology University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA ² Departments of Pediatrics University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA

Abstract:	Immunization of C57BL/6 mice with purified acetytchollne receptor(AChR) is known to induce a T cell-dependent antibody responsethat results in experimental autoimmune myasthenia gravis (EAMG).Since past observations link V_ß6⁺ T cells with a prominentAChR epitope specificity, a V_ß6-specific immunotoxin(VIT6) was tested in vitro for its ability to selectively killmonoclonal and polyclonal T cells that demonstrate reactivityagainst AChR. Results described below clearly demonstrate theability to selectively kill AChR-reactlve T cells based on theirexpression of a particular V_ß-associated antigen receptor.

Keywords:	autoimmune disease T cell receptor
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