连续多次单采血浆者低密度脂蛋白及相关复合物的氧化易感性分析

目的探讨连续多次单采血浆者氧化低密度脂蛋白(ox-LDL)、β2-糖蛋白I/氧化低密度脂蛋白(β2-GPI/ox-LDL)复合物的水平,并分析其体内低密度脂蛋白(LDL)的氧化易感性。方法分别检测60例连续多次单采血浆者和60例初次血浆单采者的ox-LDL、β2-GPI/ox-LDL复合物的水平,同时分析其LDL氧化易感性的变化。结果与初次血浆单采者相比,连续多次单采血浆者的血浆ox-LDL、β2-GPI/ox-LDL复合物水平的差异均无统计学意义,其LDL氧化延滞时间延长、氧化速率及总氧化值下降,但差异均无统计学意义。结论连续多次的血浆单采对体内ox-LDL、β2-GPI/ox-LDL复合物的水平以及LDL氧化易感性均无明显影响,不会增加其心血管疾病的风险。

The Plasma Oxidative Susceptibility of LDL, LDL Level in Long-term Successive Plasmapheresis Donors

Objectives To investigate the changes of plasma oxidized LDL （ox-LDL）, β2-glycoprotein I with ox- LDL β2-GPI/ox-LDL） levels and low density lipoprotein （LDL） oxidative susceptibility in long-term intensive plasmapheresis donors. Methods The plasma evets of ox-LDL and β2-GPI/ox-LDL were determined in 60 intensive plasmapheresis donors and 60 first-time donors, and their plasma susceptibility of LDL to in vitro oxidation was also measured. ResuLts No significant differences were found in plasma ox-LDL and β2-GPI/ox-LDL levels between the individuals undergoing long-term intensive plasmapheresis and the first-time donors. The lag time, maximal oxidation rate and total amount of conjugated dienes of LDL oxidizability were lower in intensive plasmapheresis donors, but the changes were not significant statistically. Conclusions Long-term intensive donor plasmapheresis has no statistcal effect on the plasma LDL oxidative susceptibility, ox-LDL and β2-GPI/ox-LDL levels, meanwhile successive plasma demation will not result in increasing of cardiovascular risk.