马来酸桂哌齐特注射液致急性粒细胞缺乏

1例78岁女性，因患脑梗死，应用马来酸桂哌齐特注射液160mg，1次／d静脉滴注治疗。第3天出现发热，WBC自7．32×10^9／L降至2．3×10^9／L，N自6．14×10^9／L降至1．7×10^9／L。立即停用马来酸桂哌齐特注射液，口服小檗胺和鲨肝醇。2d后，体温降至正常，WBC2．6×10^9／L，N2．0×10^9／L；2周后白细胞及中性粒细胞计数均恢复正常。随访2月血常规一直正常。

Acute agranulocytosis caused by cinepazide maleate injection

A 78-year-old woman with cerebral infarction received IV cinepazide maleate injection 160 mg once daily. On day 3, the woman experienced a fever; her WBC count decreased from 7.32 × 10^9/L to 2.3 × 10^9/L; neutrophil count decreased from 6.14 × 10^9/L to 1.7 × 10^9/L. Cinepazide maleate injection was withdrawn immediately, and berbamine and batilol were given. Two days later, her temperature fell to normal, and laboratory testing showed a WBC count of 2.6 × 10^9/L with N 2.0 × 10^9/L. Two weeks later, her WBC and neutrophil counts retured to normal limits. A follow-up period lasting two months showed that her blood routine tests remained normal.