| 冠心病患者亚甲基四氢叶酸还原酶基因多态性87例研究 |
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| 引用本文： | 肖雁,胡志恒,单可人,官志忠,任锡麟. 冠心病患者亚甲基四氢叶酸还原酶基因多态性87例研究[J]. 中国实用内科杂志, 2007, 27(4): 293-295 |
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| 作者姓名： | 肖雁 胡志恒 单可人 官志忠 任锡麟 |
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| 作者单位： | 1. 贵阳医学院分子生物学重点实验室,贵州,贵阳,550004
2. 贵阳市第二人民医院,贵州,贵阳,550005 |
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| 基金项目： | 贵州省省长基金;贵阳医学院校科研和教改项目 |
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| 摘 要： | 目的探讨N5,N10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性与冠心病的关系。方法对2003年11月至2005年8月贵阳医学院附属医院及贵州市第二人民医院住院的87例冠心病患者(冠心病组)及同期在门诊进行健康体检的73名健康人(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法检测其MTHFRC677T基因多态性。结果对照组与冠心病组MTHFR677位T等位基因的分布频率分别是18.5%,36.1%,病例组MTHFR基因C677T的CT基因型及T等位基因频率显著高于对照组,差异有显著性(P<0.05)。结论MTHFRC677T基因多态性与冠心病密切相关。
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| 关 键 词： | 亚甲基四氢叶酸还原酶 冠心病 多态性 |
| 文章编号： | 1005-2194(2007)04-0293-03 |
| 修稿时间： | 2006-07-14 |
Study on the polymorphysm of MTHFR gene in coronary heart disease in Guizhou |
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| XIAO Yan,HU Zhi-heng,SHAN Ke-ren,et al.. Study on the polymorphysm of MTHFR gene in coronary heart disease in Guizhou[J]. Chinese Journal of Practical Internal Medicine, 2007, 27(4): 293-295 |
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| Authors: | XIAO Yan HU Zhi-heng SHAN Ke-ren et al. |
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| Affiliation: | XIAO Yan,HU Zhi-heng,SHAN Ke-ren,et al.The Key Laboratory of Molecular Biology in Guiyang Medical University,Guiyang 550004,China |
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| Abstract: | Objective Study on methylenetetrahydrofolate reductase(MTHFR)gene polymorphism in coronary heart disease.Methods Detect the MTHFR C677T gene polymorphism by PCR-RFLP in 73 cases of healthy individuals and 87 cases of coronary heart diseas(CHD).Results At the site of 677,the T allele frequencies are 18.5%,36.1%,respectively,for healthy individuals and 87 cases of coronary heart disease.The frequecies of MTHFR CT genotype and T allel were significantly higher in disease groups.There are significant differences between disease group and control group(P<0.05).Conclusion MTHFR C677T gene polymorphism is associated with coronary heart disease. |
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| Keywords: | MTHFR Coronary heart disease Polymorphysm |
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