左氧氟沙星联合头孢哌酮/舒巴坦治疗肺部多药耐药杆菌感染疗效观察

目的观察左氧氟沙星联合头孢哌酮/舒巴坦治疗肺部多药耐药杆菌感染疗效。方法85例肺部多药耐药杆菌感染患者,随机分成两组,治疗组应用左氧氟沙星与头孢哌酮/舒巴坦,对照组给予头孢曲松,两组疗程均为7 d,观察临床疗效。结果治疗组痊愈34例,显效7例,进步3例,无效1例,总有效率为91%;对照组痊愈20例,显效8例,进步7例,无效5例,总有效率为70%;治疗组有效率较对照组高,差异有统计学意义(P<0.05);治疗组咳嗽、咯痰、呼吸困难等临床表现明显改善,痰培养转阴率高,较对照组疗效好。结论左氧氟沙星联合头孢哌酮/舒巴坦是治疗肺部多药耐药杆菌感染的有效方案。

Clinical Therapeutic Effect of Levofloxacin Combined with Cefoperazone-sulbactam on Pulmonary Infection Caused by Multidrug-resistant Bacillus Infection

OBJECTIVE To observe the clinical therapeutic effect of levofloxacin combined with cefoperazone-sulbactam on pulmonary infection caused by multidrug-resistant(MDR) bacillus infection.METHODS Eighty five patients with pulmonary infection caused by MDR bacillus infection were randomly divided into treatment group and control group,combined levofloxacin and cefoperazone-sulbactam were used in 45 patients of treatment group,ceftriaxone sodium was used in 40 patients of control group,their therapeutic effect was observed 7 days later.RESULTS Thirty four patients of treatment group were cured,7 patients with excellence,3 patients with improvement and only 1 patient was invalid.The total effective rate was 91%.Clinical manifestation such as cough,expectoration,and dyspnea had obviously improved.Sputum culture darkening rate was high.CONCLUSIONS Combined therapy of levofloxacin and cefoperazone-sulbactam has definite therapeutic effect on pulmonary infection caused by MDR bacillus infection.