Recombinant interferon-alpha with or without vinblastine in metastatic renal carcinoma. Results of a randomised phase II study |
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| Authors: | S D Foss? N Raabe B Moe |
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| Affiliation: | Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo. |
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| Abstract: | In a randomised phase II study, 5 of 24 patients with metastatic renal carcinoma responded to treatment with interferon (IFN) (Roferon A, Roche, Basle, Switzerland) (18 x 10(6) u i.m. 3 times/week). The combination of IFN with vinblastine (0.1 mg/kg every third week) yielded a response rate of 16% (4 of 25 patients). Three patients continue to show a response (2 complete, 1 partial) more than 20 months after cessation of treatment. Flu-like symptoms represented the major side effect and often led to modification or discontinuation of treatment. It was concluded that IFN is the treatment of choice in patients with metastatic renal carcinoma who are candidates for medical treatment. The significance of additional vinblastine is uncertain. |
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