Pancreatic Exocrine Enzymes and Intrapancreatic Protein Synthesis in Acute Oedematous Pancreatitis |
| |
| Authors: | Yoshio Kinami Ichiro Kita Yasuhiko Kojima Shigeki Takashima |
| |
| Affiliation: | 1. Division of Cancer Research, Medical Research Institute, Kanazawa Medical University, Ishikawa, Uchinada, Japan.;2. Department of Surgery II, Kanazawa Medical University, Ishikawa, Uchinada, Japan.;3. Division of Cancer Research, Medical Research Institute, Kanazawa Medical University, Uchinada-Machi, Kahoku-Gun, Ishikawa, 920-02, Japan, |
| |
| Abstract: | Changes in serum and intrapancreatic enzyme content and protein synthesis in pancreas werestudied in acute oedematous pancreatitis (AOP). Male Wistar rats (n = 111) were divided into2 groups, controls with a sham operation and those with AOP. Serum amylase levels roseimmediately after the procedure causing AOP and then fell gradually, while serum lipase andribonuclease levels remained higher than control values over 48h. (p < 0.05, 0.01). Serumdeoxyribonuclease (DNase) II levels were unchanged. Intrapancreatic enzyme levels werescarcely affected by AOP. 3H-leucine uptake into pancreatic tissue of rats with AOP wasdecreased throughout the study (p < 0.001), but some protein synthesis continued. Intrapancreaticenzyme contents are maintained despite diffusion into the blood because the pancreasretain its ability to synthesize enzymes. |
| |
| Keywords: | |
|
|
