| 舒心饮预防动脉粥样硬化的实验研究 |
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| 引用本文： | 汤诺,何燕,沈琳,林钟香.舒心饮预防动脉粥样硬化的实验研究[J].辽宁中医杂志,2009(10):1800-1802. |
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| 作者姓名： | 汤诺 何燕 沈琳 林钟香 |
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| 作者单位： | 上海中医药大学附属龙华医院心内科; |
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| 基金项目： | 国家自然科学基金青年项目(30600827);;2007年上海市卫生局资助项目(2007120) |
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| 摘 要： | 目的:通过研究舒心饮对动脉粥样硬化形成过程中相关致炎因子的影响和量效关系,阐明舒心饮干预和延缓动脉粥样硬化形成的可能机制。方法:72只雄性SD大鼠被随机均分为空白组、模型组、舒降之组、舒心饮低、中、高剂量组。观察血脂、光镜下胸主动脉的病理变化、胸主动脉内膜致炎因子MCP-1、P-selectin蛋白的表达。结果:舒心饮能显著降低血清总胆固醇,升高HDL/TC的比值;显著降低动脉内膜厚度、泡沫细胞阳性内膜面积及其占内膜总面积的百分比;舒心饮能显著降低P-selectin、MCP-1在大鼠胸主动脉内膜的表达;中剂量舒心饮也许是抗动脉粥样硬化治疗的最佳剂量。结论:舒心饮能影响动脉粥样硬化形成过程中炎症的启动和致炎因子的激活,延缓动脉粥样硬化的进程,预防和治疗动脉粥样硬化性疾病。
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| 关 键 词： | 舒心饮 动脉粥样硬化 炎症 致炎因子 |
Experimental Study on Effects of ShuXinYin on Prevention of Atherosclerosis |
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| TANG Nuo,HE Yan,SHEN Lin,LIN Zhong-xiang.Experimental Study on Effects of ShuXinYin on Prevention of Atherosclerosis[J].Liaoning Journal of Traditional Chinese Medicine,2009(10):1800-1802. |
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| Authors: | TANG Nuo HE Yan SHEN Lin LIN Zhong-xiang |
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| Institution: | Department of Cardiology;Longhua Hospital Affiliated to Shanghai Universitty of Traditional Chinese Medicine;Shanghai 200032;China |
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| Abstract: | Objective:To study the dose-effects relationship and mechanisms of ShuXinYin(SXY)on prevention of the development of inflammation in atherosclerosis.Methods:72 male SD rats were randomly divided into 6 groups including the untreated,model,simvatatin,Low-dose SXY,Medium-dose SXY and High-dose SXY.Study items were biochemical indicators including TC,TG,HDL,LDL and HDL/TC,pathological examination of the thoracic aorta including arterial intimal thickness,foam cell-containing areas and percentage of foam cell-c... |
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| Keywords: | ShuXinYin Atherosclerosis Inflammation Proinflammatory factors |
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