Vancomycin pharmacokinetics in patients with severe burn injuries |
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Authors: | Michael Dolton Hongmei Xu Elaine Cheong Peter Maitz Peter Kennedy Thomas Gottlieb Evette Buono Andrew J. McLachlan |
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Affiliation: | 1. Faculty of Pharmacy, University of Sydney, Sydney, NSW, 2006, Australia;2. Burns Unit, Concord Repatriation General Hospital, Hospital Road, Concord, NSW, 2139, Australia;3. Department of Microbiology and Infectious Diseases, Concord Repatriation General Hospital, Hospital Road, Concord, Sydney, NSW, 2139, Australia;4. Pharmacy Department, Concord Repatriation General Hospital, Hospital Road, Concord, Sydney, NSW, 2139, Australia;5. Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Hospital Road, Concord, Sydney, NSW, 2139, Australia |
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Abstract: | Vancomycin is used in patients with severe burns and methicillin-resistant Staphylococcus aureus (MRSA) infection. This study investigated vancomycin pharmacokinetics in people with burns in comparison to people without burns and examined the factors contributing to pharmacokinetic variability. This was a retrospective, case-control study of hospitalised burns patients compared with a control patient cohort administered vancomycin without burn injury. Vancomycin pharmacokinetic parameters were determined using therapeutic drug monitoring data and a population pharmacokinetic modelling approach employing a two-compartment pharmacokinetic model. The impact of patient characteristics on vancomycin clearance was explored. Vancomycin clearance was significantly higher (p < 0.001) in burns patients (5.9 ± 3.1 L/h, n = 37) when compared to control patients (3.4 ± 1.8 L/h, n = 33), as was estimated creatinine clearance, which was correlated to drug clearance in burns patients (r2 = 0.64). There was no significant change in volume of distribution between patient groups. The majority of patients received a dosing regimen of 1 g twice daily, resulting in significantly (p = 0.004) lower serum trough concentrations in patients with burns (median, 6.4 mg/L; range, 0.2–22.3 mg/L) than control (median, 9.2 mg/L; range, 4.0–29.8 mg/L). Higher clearance and lower serum vancomycin concentrations in people with severe burn may increase the risk of suboptimal bactericidal action and the development of resistance highlighting the need for dosage individualisation. |
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Keywords: | Vancomycin Burn injury Pharmacokinetics Clearance MRSA |
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